Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Every person carries a vast repertoire of CD4+ T-helper cells and CD8+ cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a single T cell commits to become either CD4+ or CD8+...

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Bibliographic Details
Main Authors: Paul L Klarenbeek, Marieke E Doorenspleet, Rebecca E E Esveldt, Barbera D C van Schaik, Neubury Lardy, Antoine H C van Kampen, Paul P Tak, Robert M Plenge, Frank Baas, Paul I W de Bakker, Niek de Vries
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4627806?pdf=render

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http://europepmc.org/articles/PMC4627806?pdf=render

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