Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR). Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypothesized that chordomas resistant to PDGFR inhibiti...

Full description

Bibliographic Details
Main Authors: Dae-Hee Lee, Ying Zhang, Amin B Kassam, Myung-Jin Park, Paul Gardner, Daniel Prevedello, Stephanie Henry, Craig Horbinski, Jan H Beumer, Hussein Tawbi, Brian J Williams, Mark E Shaffrey, Merrill J Egorin, Roger Abounader, Deric M Park
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4527706?pdf=render

Internet

http://europepmc.org/articles/PMC4527706?pdf=render

Similar Items