Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1 extends the shortened lifespan of yeast, fly, and...

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Bibliographic Details
Main Authors: Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Genetics
Subjects:
S6K1
mTORC1
liver
lifespan
mitochondrial disease
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00113/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2017.00113/full

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