Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

Tumor-specific CD8+T cells are exposed to persistent antigenic stimulation which induces a dysfunctional state called “exhaustion.” Though functioning to limit damage caused by immune response, T cell exhaustion leads to attenuated effector function whereby cytotoxic CD8+T cells fail to control tumo...

Full description

Bibliographic Details
Main Authors: Weiqin Jiang, Yinjun He, Wenguang He, Guosheng Wu, Xile Zhou, Qinsong Sheng, Weixiang Zhong, Yimin Lu, Yongfeng Ding, Qi Lu, Feng Ye, Hanju Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cell exhaustion
CD8+ T cell activation
differentiation
immunotherapy
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.622509/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.622509/full

Similar Items