L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2 mediated control of cochlear BDNF expression

L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2 mediated control of cochlear BDNF expression

Voltage-gated L-type Ca2+ channels (L-VGCCs) like CaV1.2 are assumed to play a crucial role for controlling release of trophic peptides including brain-derived neurotrophic factor (BDNF). In the inner ear of the adult mouse, beside the well described L-VGCC CaV1.3, also CaV1.2 is expressed. Due to l...

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Bibliographic Details
Main Authors: Annalisa eZuccotti, Sze Chim eLee, Dario eCampanelli, Wibke eSinger, Somisetty Venkata eSatheesh, Tommaso ePatriarchi, Hyun-Soon eGeisler, Iris eKöpschall, Karin eRohbock, Hans Gerd eNothwang, Jing eHu, Johannes W. eHell, Thomas eSchimmang, Lukas eRüttiger, Marlies eKnipper
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
BDNF
ABR
Inner ear
SOC
L-VGCCs
CaV1.2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00020/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00020/full

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