Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

Background: In many cancer cells, L-type amino acid transporter 1 (LAT1) transports neutral amino acids with bulky side chain, which activate mammalian target of rapamycin (mTOR) to cause cell proliferation. An anti-diabetic drug, metformin, has been shown to activate AMP-activated protein kinase (A...

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Bibliographic Details
Main Authors: Seiji Ueno, Toru Kimura, Takashi Yamaga, Akihiko Kawada, Toshiaki Ochiai, Hitoshi Endou, Hiroyuki Sakurai
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Pharmacological Sciences
Subjects:
L-type amino acid transporter 1
Metformin
Mammalian target of rapamycin
AMP-activated protein kinase
Head and neck cancer cells
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131630038X

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http://www.sciencedirect.com/science/article/pii/S134786131630038X

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