A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia

The number of tRNA isodecoders has expanded significantly during evolution, which has resulted in ambiguity in tRNA selection by synthetases. Here the authors identify and characterize a dedicated proofreading factor that eliminates errors caused by ambiguity in tRNA selection by eukaryotic tRNA syn...

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Bibliographic Details
Main Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan Sankaranarayanan
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02204-w