Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

Poly(I:C) acts on dendritic cells to induce potent antitumor effects through the production of cytokines/interferons, activation of natural killer cells and proliferation of cytotoxic T lymphocytes. In some tumor or myeloid lineages, poly(I:C) seemed to induce necroptosis in concert with a pan-caspa...

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Bibliographic Details
Main Authors: Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
interferon
necroptosis
tlr3/ticam-1 pathway
viral rna
Online Access:http://dx.doi.org/10.1080/2162402X.2015.1078968

Internet

http://dx.doi.org/10.1080/2162402X.2015.1078968

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