Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam

Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam

Background/Aim. The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively polisynaptic routes by stimulating inhibitory action of GABA. The aim of the present study was to examine the effects of combined application of...

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Bibliographic Details
Main Authors: Šegrt Zoran, Đorđević Snežana, Jaćević Vesna, Kilibarda Vesna, Vučinić Slavica, Jović-Stošić Jasmina, Potrebić Olivera, Vukčević-Perković Nataša
Format: Article
Language:English
Published: Military Health Department, Ministry of Defance, Serbia 2009-01-01
Series:Vojnosanitetski Pregled
Subjects:
poisoning
benzodiazepines
flumazenil
theophylline
rats
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500902141S.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500902141S.pdf

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