The Infectious Basis of ACPA-Positive Rheumatoid Arthritis

The Infectious Basis of ACPA-Positive Rheumatoid Arthritis

Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gin...

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Bibliographic Details
Main Authors: Lazaros I. Sakkas, Dimitrios Daoussis, Stamatis-Nick Liossis, Dimitrios P. Bogdanos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Microbiology
Subjects:
anti-citrullinated protein antibodies
arthritis
Ebstein-Barr virus
HLA-DRB1 shared epitope
Porphyromonas gingivalis
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01853/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01853/full

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