The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of <i>p21</i>, <i>HDM2</i>, <i>BCL2</i> and <i>MCL1</i> Genes in Chronic Lymphocytic Leukemia
Malignant cells in chronic lymphocytic leukemia (CLL) show resistance to apoptosis, as well as to chemotherapy, which are related to deletions or mutations of <i>TP53</i>, high expression of <i>MCL1</i> and <i>BCL2</i> genes and other abnormalities. Thus, the main...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/5/1088 |