Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem-difluoroalkyl side chain by cyclocondensations in goo...

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Bibliographic Details
Main Authors: Assaad Nasr El Dine, Ali Khalaf, Danielle Grée, Olivier Tasseau, Fares Fares, Nada Jaber, Philippe Lesot, Ali Hachem, René Grée
Format: Article
Language:English
Published: Beilstein-Institut 2013-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
19F/1H HOESY
gem-difluoroalkyl derivatives
organo-fluorine compounds
palladium catalysis
pyrazolines
pyrrolines
Online Access:https://doi.org/10.3762/bjoc.9.230

Internet

https://doi.org/10.3762/bjoc.9.230

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