Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively. Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis. Design, setting, and participants: We applied multiplex immunofluorescence and targ...

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Bibliographic Details
Main Authors: Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:European Urology Open Science
Subjects:
Prostate cancer
Tumor microenvironment
Immune cells
Lymph node
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168321000859

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http://www.sciencedirect.com/science/article/pii/S2666168321000859

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