Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice

Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice

Pyroptosis is a recently characterized inflammatory form of programmed cell death that is thought to be involved in the pathogenesis of perioperative neurocognitive disorders (PND). Elamipretide (SS-31), a mitochondrial-targeted peptide with multiple pharmacological properties, including anti-inflam...

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Bibliographic Details
Main Authors: Youmei Zuo, Lei Yin, Xinqi Cheng, Jun Li, Hao Wu, Xuesheng Liu, Erwei Gu, Jing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
perioperative neurocognitive disorders
elamipretide
mitochondria
pyroptosis
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00251/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00251/full

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