Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...

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Bibliographic Details
Main Authors: Amani S. Awaad, Ahmed M. Alafeefy, Fatmah A.S. Alasmary, Reham M. El-Meligy, M.E. Zain, Saleh I. Alqasoumi
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016417300336