Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

Severe and recurrent cisplatin-induced acute kidney injury (AKI) as part of standard cancer therapy is a known risk factor for development of chronic kidney disease (CKD). The specific role of superoxide (O2•-)-mediated disruption of mitochondrial oxidative metabolism in CKD after cisplatin treatmen...

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Bibliographic Details
Main Authors: Kranti A. Mapuskar, Hsiang Wen, Danniele G. Holanda, Prerna Rastogi, Emily Steinbach, Rachel Han, Mitchell C. Coleman, Massimo Attanasio, Dennis P. Riley, Douglas R. Spitz, Bryan G. Allen, Diana Zepeda-Orozco
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718308024

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http://www.sciencedirect.com/science/article/pii/S2213231718308024

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