Therapeutic Efficacy of Adenoviral-Mediated p53 Gene Transfer Is Synergistically Enhanced by Combined Use of Antisense Oligodeoxynucleotide Targeting Clusterin Gene in a Human Bladder Cancer Model

Therapeutic Efficacy of Adenoviral-Mediated p53 Gene Transfer Is Synergistically Enhanced by Combined Use of Antisense Oligodeoxynucleotide Targeting Clusterin Gene in a Human Bladder Cancer Model

To establish a more effective therapeutic strategy against advanced bladder cancer, we investigated the effects of combined treatment with antisense (AS) oligodeoxynucleotide (ODN) targeting the antiapoptotic gene clusterin and adenoviral-mediated p53 gene transfer (Ad5CMV-p53) using the human blad...

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Bibliographic Details
Main Authors: Hideaki Miyake, Kazuki Yamanaka, Mototsugu Muramaki, Isao Hara, Martin E. Gleave
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Bladder cancer
clusterin
apoptosis
p53
metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800181

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http://www.sciencedirect.com/science/article/pii/S1476558605800181

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