Synthesis of Oligonucleotides Containing 2′-<i>N</i>-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) Moieties Using Post-Synthetic Modification Strategy

Synthesis of Oligonucleotides Containing 2′-<i>N</i>-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) Moieties Using Post-Synthetic Modification Strategy

The post-synthetic modification of an oligonucleotide is a powerful strategy for the synthesis of various analogs of the oligonucleotide, aiming to achieve the desired functions. In this study, we synthesized the thymidine phosphoramidite of 2&#8242;-<i>N</i>-pentafluorophenoxycarbon...

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Bibliographic Details
Main Authors: Shoko Yamashita, Kodai Nishida, Takashi Osawa, Ayumi Nakanishi, Yuta Ito, Yoshiyuki Hari
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
bridged nucleic acid
post-synthetic modification
modified oligonucleotides
2′-urea-lna
uv-melting experiment
Online Access:https://www.mdpi.com/1420-3049/25/2/346

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https://www.mdpi.com/1420-3049/25/2/346

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