Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

Abstract Background Patients with lymph node (LN) metastatic bladder cancer (BCa) present with extremely poor prognosis. BCa‐derived exosomes function as crucial bioactive cargo carriers to mediate the signal transduction in tumor microenvironment triggering tumor metastasis. However, the mechanisms...

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Bibliographic Details
Main Authors: Hanhao Zheng, Changhao Chen, Yuming Luo, Min Yu, Wang He, Mingjie An, Bowen Gao, Yao Kong, Yiyao Ya, Yan Lin, Yuting Li, Keji Xie, Jian Huang, Tianxin Lin
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Clinical and Translational Medicine
Subjects:
BCYRN1
bladder cancer
exosomes
lymph node metastasis
VEGF‐C/VEGFR3 signaling
Online Access:https://doi.org/10.1002/ctm2.497

Internet

https://doi.org/10.1002/ctm2.497

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