Impact of RNA editing on functions of the serotonin 2C receptor <i>in vivo</i>

Impact of RNA editing on functions of the serotonin 2C receptor <i>in vivo</i>

Transcripts encoding 5-HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT2C-VGV, exhibits blunted G-protein coupling and reduced constitutive activity. The present studies examine the signal t...

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Bibliographic Details
Main Authors: Uade B Olaghere Da Silva, Michael V Morabito, Clinton E Canal, David C Airey, Ronald B Emeson, Elaine Sanders-Bush
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-03-01
Series:Frontiers in Neuroscience
Subjects:
Behavior
RNA Editing
Serotonin
Signal Transduction
5-HT2C
5-HT2C agonist
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.23.001.2010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/neuro.23.001.2010/full

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