Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca<sup>2+</sup>: A Molecular Dynamics Study

Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca<sup>2+</sup>: A Molecular Dynamics Study

Mutant huntingtin (m-HTT) proteins and calmodulin (CaM) co-localize in the cerebral cortex with significant effects on the intracellular calcium levels by altering the specific calcium-mediated signals. Furthermore, the mutant huntingtin proteins show great affinity for CaM that can lead to a furthe...

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Bibliographic Details
Main Authors: Sanda Nastasia Moldovean, Vasile Chiş
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
calmodulin
calcium-binding protein
polyglutamine tract
polyglutamine disorders
Huntington’s disease
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/22/16/9025

Internet

https://www.mdpi.com/1422-0067/22/16/9025

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