Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer's disease

Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer's disease

Accumulation of amyloid β (Aβ) induces neuronal, synaptic, and cognitive deficits in patients and animal models of Alzheimer's disease (AD). The underlying mechanisms, however, remain to be fully elucidated. In the present study, we found that Aβ interacted with ErbB4, a member of the receptor...

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Bibliographic Details
Main Authors: Heng Zhang, Ling Zhang, Dongming Zhou, Xiao He, Dongpi Wang, Hongyu Pan, Xiaoqin Zhang, Yufei Mei, Qi Qian, Tingting Zheng, Frank E. Jones, Binggui Sun
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid β
ErbB4
PV neurons
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301535

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http://www.sciencedirect.com/science/article/pii/S0969996117301535

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