AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction

AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction

Abstract The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial‐to‐mesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL inhibition in kidney fibrosis due to unilateral ureteral obstructio...

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Bibliographic Details
Main Authors: Lea Landolt, Jessica Furriol, Janka Babickova, Lavina Ahmed, Øystein Eikrem, Trude Skogstrand, Andreas Scherer, Salwa Suliman, Sabine Leh, James B. Lorens, Gro Gausdal, Hans‐Peter Marti, Tarig Osman
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Physiological Reports
Subjects:
AXL targeting
Bemcentinib (BGB324)
renal fibrosis
UUO
Online Access:https://doi.org/10.14814/phy2.14091

Internet

https://doi.org/10.14814/phy2.14091

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