Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Transplantation Improved Osteogenesis in Infants with Severe Hypophosphatasia

Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Transplantation Improved Osteogenesis in Infants with Severe Hypophosphatasia

Patients with severe hypophosphatasia (HPP) develop osteogenic impairment with extremely low alkaline phosphatase (ALP) activity, resulting in a fatal course during infancy. Mesenchymal stem cells (MSCs) differentiate into various mesenchymal lineages, including bone and cartilage. The efficacy of a...

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Bibliographic Details
Main Authors: Takeshi Taketani M.D., Ph.D., Chigusa Oyama, Aya Mihara, Yuka Tanabe, Mariko Abe, Tomohiro Hirade, Satoshi Yamamoto, Ryosuke Bo, Rie Kanai, Taku Tadenuma, Yuko Michibata, Soichiro Yamamoto, Miho Hattori, Yoshihiro Katsube, Hiroe Ohnishi, Mari Sasao, Yasuaki Oda, Koji Hattori, Shunsuke Yuba, Hajime Ohgushi, Seiji Yamaguchi
Format: Article
Language:English
Published: SAGE Publishing 2015-10-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X685410

Internet

https://doi.org/10.3727/096368914X685410

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