Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency...

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Bibliographic Details
Main Authors: Shoudong Ye, Tao Zhang, Chang Tong, Xingliang Zhou, Kan He, Qian Ban, Dahai Liu, Qi-Long Ying
Format: Article
Language:English
Published: The Company of Biologists 2017-04-01
Series:Biology Open
Subjects:
Differentiation
Embryonic stem cells
LEF1
Self-renewal
TCF3
Online Access:http://bio.biologists.org/content/6/4/511

Internet

http://bio.biologists.org/content/6/4/511

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