Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease

Abstract Background Multiple risk factors contribute to the progression of Parkinson’s disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this associa...

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Bibliographic Details
Main Authors: Li-Hui Bao, Ya-Nan Zhang, Jian-Nan Zhang, Li Gu, Hui-Min Yang, Yi-Ying Huang, Ning Xia, Hong Zhang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Urate
Microglia
Inflammation
Urate transporter
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s12974-018-1175-8

Internet

http://link.springer.com/article/10.1186/s12974-018-1175-8

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