Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer

Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer

Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR in colorectal cancer (CRC) by disclosing increased HMGR activity in CRC patients...

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Bibliographic Details
Main Authors: Tzu-Tang Wei, Yi-Ting Lin, Wen-Shu Chen, Ping Luo, Yu-Chin Lin, Chia-Tung Shun, Yi-Hsin Lin, Jhih-Bin Chen, Nai-Wei Chen, Jim-Min Fang, Ming-Shiang Wu, Kai-Chien Yang, Li-Chun Chang, Kang-Yu Tai, Jin-Tung Liang, Ching-Chow Chen
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:EBioMedicine
Subjects:
Colorectal cancer
HMG-CoA reductase
Histone deacetylase
Statin hydroxamate
Preclinical model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303243

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http://www.sciencedirect.com/science/article/pii/S2352396416303243

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