ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.

ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.

Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy in colorectal cancer cells, and inhibition of the autophagy p...

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Bibliographic Details
Main Authors: Haiyuan Zhang, Yunlong Lei, Ping Yuan, Lingjun Li, Chao Luo, Rui Gao, Jun Tian, Zuohua Feng, Edouard C Nice, Jun Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4014500?pdf=render

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http://europepmc.org/articles/PMC4014500?pdf=render

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