Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts

Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts

Heavy metals, such as lead (Pb2+), are usually accumulated in human bodies and impair human's health. Lead is a metal with many recognized adverse health side effects and yet the molecular processes underlying lead toxicity are still poorly understood. In the present study, we proposed to inves...

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Bibliographic Details
Main Authors: Li Sui, Rui‑Hong Zhang, Ping Zhang, Ke‑Li Yun, Hong‑Cai Zhang, Li Liu, Ming‑Xu Hu
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2015-03-01
Series:Bioscience Reports
Subjects:
autophagy
cardiofibroblasts
endoplasmic reticulum (ER) stress
lead toxicity
mammalian target of rapamycin (mTOR) pathway
Online Access:http://www.bioscirep.org/bsr/035/e186/bsr035e186.htm

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http://www.bioscirep.org/bsr/035/e186/bsr035e186.htm

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