Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage

Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage

Bruton tyrosine kinase (BTK) sits at the crossroads of adaptive and innate immunities. Nevertheless, the detailed role of BTK activation in hepatic inflammatory disorders is still elusive to date. Accordingly, we investigated the impact of blocking BTK activation by acalabrutinib (ACB) on lipopolysa...

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Bibliographic Details
Main Authors: Mohamed E. Shaker, Hesham A.M. Gomaa, Khalid S. Alharbi, Mohammad M. Al-Sanea, Mohamed E. El-Mesery, Sara H. Hazem
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acalabrutinib
Bruton tyrosine kinase
Galactosamine
Inflammation
Lipopolysaccharide
PAMPs
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030929X

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http://www.sciencedirect.com/science/article/pii/S075333222030929X

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