Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs. FBDD has evolved and grown in popularity over the past 15 years. In this paper, the...

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Bibliographic Details
Main Authors: Aaron J. Oakley, Zorik Chilingaryan, Zhou Yin
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:International Journal of Molecular Sciences
Subjects:
fragment-based screening
crystallography
drug design
synchrotron radiation
X-ray
Online Access:http://www.mdpi.com/1422-0067/13/10/12857

Internet

http://www.mdpi.com/1422-0067/13/10/12857

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