Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice

Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice

Zotarolimus is a semi-synthetic derivative of rapamycin and an inhibitor of mammalian target of rapamycin (mTOR) signaling. Currently, zotarolimus is used to prolong the survival time of organ grafts, but it is also a novel immunosuppressive agent with potent anti-proliferative activity. Here, we ex...

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Bibliographic Details
Main Authors: Geng-Ruei Chang, Chan-Yen Kuo, Ming-Yang Tsai, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chung-Hung Chen, Yu-Chen Wang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
5-fluorouracil
colorectal adenocarcinoma
inflammation
metastasis
zotarolimus
Online Access:https://www.mdpi.com/1420-3049/26/15/4683

Internet

https://www.mdpi.com/1420-3049/26/15/4683

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