Proteasome activity influences UV-mediated subnuclear localization changes of NPM.

Proteasome activity influences UV-mediated subnuclear localization changes of NPM.

UV damage activates cellular stress signaling pathways, causes DNA helix distortions and inhibits transcription by RNA polymerases I and II. In particular, the nucleolus, which is the site of RNA polymerase I transcription and ribosome biogenesis, disintegrates following UV damage. The disintegratio...

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Bibliographic Details
Main Authors: Henna M Moore, Baoyan Bai, Olli Matilainen, Laureen Colis, Karita Peltonen, Marikki Laiho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3595268?pdf=render

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http://europepmc.org/articles/PMC3595268?pdf=render

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