Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom

Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom

We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee (Apis mellifera) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of...

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Main Authors: Alexandre Naime Barbosa, Rui Seabra Ferreira, Francilene Capel Tavares de Carvalho, Fabiana Schuelter-Trevisol, Mônica Bannwart Mendes, Bruna Cavecci Mendonça, José Nixon Batista, Daisson José Trevisol, Leslie Boyer, Jean-Philippe Chippaux, Natália Bronzatto Medolago, Claudia Vilalva Cassaro, Márcia Tonin Rigotto Carneiro, Ana Paola Piloto de Oliveira, Daniel Carvalho Pimenta, Luís Eduardo Ribeiro da Cunha, Lucilene Delazari dos Santos, Benedito Barraviera
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
antivenom
Apis mellifera (Africanized)
clinical trial
safety assessment
enzyme-linked immunosorbent assay (ELISA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653151/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.653151/full

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