CRISPR/Cas9-mediated targeted chromosome elimination

CRISPR/Cas9-mediated targeted chromosome elimination

Abstract Background The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown...

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Main Authors: Erwei Zuo, Xiaona Huo, Xuan Yao, Xinde Hu, Yidi Sun, Jianhang Yin, Bingbing He, Xing Wang, Linyu Shi, Jie Ping, Yu Wei, Wenqin Ying, Wei Wei, Wenjia Liu, Cheng Tang, Yixue Li, Jiazhi Hu, Hui Yang
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-017-1354-4

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http://link.springer.com/article/10.1186/s13059-017-1354-4

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