Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate, likely involving the action of both pyruvate carboxyla...

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Bibliographic Details
Main Authors: Caroline M. Voss, Lene Arildsen, Jakob D. Nissen, Helle S. Waagepetersen, Arne Schousboe, Pierre Maechler, Peter Ott, Hendrik Vilstrup, Anne B. Walls
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
glutamate dehydogenase
brain
hyperammonemia
glutamate
alanine
pyruvate carboxylase (PC)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.646291/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.646291/full

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