Hypoxia affects neprilysin expression through caspase activation and an APP intracellular domain-dependent mechanism

Hypoxia affects neprilysin expression through caspase activation and an APP intracellular domain-dependent mechanism

While gene mutations in the amyloid precursor protein (APP) and the presenilins lead to an accumulation of the amyloid β-peptide (Aβ) in the brain causing neurodegeneration and familial Alzheimer’s disease (AD), over 95% of all AD cases are sporadic. Despite the pathologies being indistinguishable,...

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Bibliographic Details
Main Authors: Caroline eKerridge, Daria I. Kozlova, Natalia N Nalivaeva, Anthony J Turner
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Neuroscience
Subjects:
Caspases
Neprilysin
hypoxia
APP
AICD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00426/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00426/full

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