Exercise Training and Neurodegeneration in Mitochondrial Disorders: Insights From the Harlequin Mouse

Exercise Training and Neurodegeneration in Mitochondrial Disorders: Insights From the Harlequin Mouse

AimCerebellar neurodegeneration is a main phenotypic manifestation of mitochondrial disorders caused by apoptosis-inducing factor (AIF) deficiency. We assessed the effects of an exercise training intervention at the cerebellum and brain level in a mouse model (Harlequin, Hq) of AIF deficiency.Method...

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Bibliographic Details
Main Authors: Miguel Fernández-de la Torre, Carmen Fiuza-Luces, Pedro L. Valenzuela, Sara Laine-Menéndez, Joaquín Arenas, Miguel A. Martín, Doug M. Turnbull, Alejandro Lucia, María Morán
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
Harlequin mouse
mitochondrial diseases
neurodegeneration
OXPHOS disorders
training
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.594223/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.594223/full

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