Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis

Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis

Abstract Background In multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), inflammation is perpetuated by both infiltrating leukocytes and astrocytes. Recent work implicated SUR1-TRPM4 channels, expressed mostly by astrocytes, in murine EAE. We tested the hypothesis that pha...

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Bibliographic Details
Main Authors: Volodymyr Gerzanich, Tapas K. Makar, Poornachander Reddy Guda, Min Seong Kwon, Jesse A. Stokum, Seung Kyoon Woo, Svetlana Ivanova, Alexander Ivanov, Rupal I. Mehta, Alexandra Brooke Morris, Joseph Bryan, Christopher T. Bever, J. Marc Simard
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
SUR1
TRPM4
SUR1-TRPM4 channel
Abcc8
Online Access:http://link.springer.com/article/10.1186/s12974-017-0953-z

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http://link.springer.com/article/10.1186/s12974-017-0953-z

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