Transcription pausing regulates mouse embryonic stem cell differentiation

Transcription pausing regulates mouse embryonic stem cell differentiation

The pluripotency of embryonic stem cells (ESCs) relies on appropriate responsiveness to developmental cues. Promoter-proximal pausing of RNA polymerase II (Pol II) has been suggested to play a role in keeping genes poised for future activation. To identify the role of Pol II pausing in regulating ES...

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Bibliographic Details
Main Authors: Melodi Tastemel, Aishwarya A. Gogate, Venkat S. Malladi, Kim Nguyen, Courtney Mitchell, Laura A. Banaszynski, Xiaoying Bai
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Stem Cell Research
Subjects:
Transcription pausing
Mouse embryonic stem cell
Global run-on sequencing (GRO-seq)
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117302428

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http://www.sciencedirect.com/science/article/pii/S1873506117302428

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