Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice

Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice

Myostatin, a transforming growth factor-β family member, is a negative regulator of skeletal muscle development and growth. Piedmontese cattle breeds have a missense mutation, which results in a cysteine to tyrosine substitution in the mature myostatin protein (C313Y). This loss-of-function mutatio...

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Bibliographic Details
Main Authors: Dezun Ma, Pengfei Gao, Lili Qian, Qingqing Wang, Chunbo Cai, Shengwang Jiang, Gaojun Xiao, Wentao Cui
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
porcine myostatin
transgenic mice
muscle growth
androgen receptor 45
Online Access:http://www.mdpi.com/1422-0067/16/8/20020

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http://www.mdpi.com/1422-0067/16/8/20020

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