Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery

Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery

Hexoses are the major source of energy and carbon skeletons for biosynthetic processes in all kingdoms of life. Their cellular uptake is mediated by specialized transporters, including glucose transporters (GLUT, SLC2 gene family). Malfunction or altered expression pattern of GLUTs in humans is asso...

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Bibliographic Details
Main Authors: Sina Schmidl, Cristina V. Iancu, Jun-yong Choe, Mislav Oreb
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
glucose transport
sugar transport inhibitors
screening system
sugar transport assays
drug discovery
hxt0 strain
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00183/full

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https://www.frontiersin.org/article/10.3389/fchem.2018.00183/full

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