Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa

Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa

Abstract Background Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C), and versican (VCANM) in plasma as biomarkers for predicting progressio...

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Bibliographic Details
Main Authors: Song Wang, Cecilie L. Bager, Morten A. Karsdal, Dimitrios Chondros, Darin Taverna, Nicholas Willumsen
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Translational Medicine
Subjects:
Biomarkers
Plasma
Collagen
Pegvorhyaluronidase alfa
PEGPH20
Pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.1186/s12967-021-02701-z

Internet

https://doi.org/10.1186/s12967-021-02701-z

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