Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models

Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models

<p>Abstract</p> <p>Background</p> <p>Toll-like receptor (TLR)3 ligands serve as natural inducers of pro-inflammatory cytokines capable of promoting Type-1 adaptive immunity, and TLR3 is abundantly expressed by cells within the central nervous system (CNS). To improve th...

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Bibliographic Details
Main Authors: Eguchi Junichi, Dusak Jill E, Fujita Mitsugu, Sasaki Kotaro, Nishimura Fumihiko, Zhu Xinmei, Fellows-Mayle Wendy, Storkus Walter J, Walker Paul R, Salazar Andres M, Okada Hideho
Format: Article
Language:English
Published: BMC 2007-02-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/5/1/10

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http://www.translational-medicine.com/content/5/1/10

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