Prevention of Antigen-Induced Bronchial Hyperreactivity and Airway Inflammation in Sensitized Guinea-Pigs by Tacrolimus

Prevention of Antigen-Induced Bronchial Hyperreactivity and Airway Inflammation in Sensitized Guinea-Pigs by Tacrolimus

We examined the effect of the immunosuppressive agent, tacrolimus (FK506), on antigen-induced bronchial hyperreactivity to acetylcholine and leukocyte infiltration into the airways of ovalbumin-challenged guinea-pigs. Subcutaneous injection of 0.5 mg/kg of FK506, 1 h before and 5 h after intra-nasal...

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Bibliographic Details
Main Authors: J. R. Lapa e Silva, C. Ruffié, J. Lefort, M-A. Nahori, B. B. Vargaftig, M. Pretolani
Format: Article
Language:English
Published: Hindawi Limited 1999-01-01
Series:Mediators of Inflammation
Subjects:
T-lymphocytes
Eosinophils
Immunohistochemistry
Immunosuppressive drugs
α4-integrins.
Online Access:http://dx.doi.org/10.1080/09629359990676

Internet

http://dx.doi.org/10.1080/09629359990676

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