Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway

Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway

BackgroundStroke remains a leading cause of adult disability and the demand for stroke rehabilitation services is growing, and Astragaloside IV (As IV), a primary bioactive compound of Radix Astragali : Astragalus mongholicus Bunge (Fabaceae), may be a promising stroke therapy.MethodsTo access the e...

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Bibliographic Details
Main Authors: Li Sun, Heming Zhang, Wen Wang, Zhiyang Chen, Shuang Wang, Jiangjing Li, Guangyao Li, Changjun Gao, Xude Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV
hippocampus
IL-17
neural stem cell
neurogenesis
stroke
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00421/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00421/full

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