Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect

Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect

Bisphosphonates (BPs) reduce bone pain and fractures by balancing the osteoblast/osteoclast ratio. The behavior of ion channels in the presence of BPs is not known. To investigate this, the effect of zoledronic acid BP (ZOL) (3 &#215; 10<sup>&#8722;8</sup> to 5 &#215; 10<s...

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Bibliographic Details
Main Authors: Rosa Scala, Fatima Maqoud, Mariacristina Angelelli, Ramon Latorre, Maria Grazia Perrone, Antonio Scilimati, Domenico Tricarico
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
TRPV1 channel
zoledronic acid
voltage dependent potassium channel
osteoblast
osteoclast
bisphosphonates
cell proliferation
mineralization
Online Access:https://www.mdpi.com/2072-6694/11/2/206

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https://www.mdpi.com/2072-6694/11/2/206

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