WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients with focal segmental glomerulosclerosis (FSGS) and me...

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Bibliographic Details
Main Authors: Natalya V. Kaverina, Diana G. Eng, Andrea D. Largent, Ilse Daehn, Anthony Chang, Kenneth W. Gross, Jeffrey W. Pippin, Peter Hohenstein, Stuart J. Shankland
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
progenitor
regeneration
glomerulus
synaptopodin
p57
enalapril
FSGS
MET
mesenchymal-to-epithelial transformation
membranous nephropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303776

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http://www.sciencedirect.com/science/article/pii/S2213671117303776

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