Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

<p>Abstract</p> <p>Background</p> <p>CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular...

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Bibliographic Details
Main Authors: Weng Yuan-Yuan, Xu Hui-Yun, Wang Zhe, Gao Xiang, Yang Peng-Fei, Cao Jian-Ping, Zhang Wei, Qian Ai-Rong, Shang Peng
Format: Article
Language:English
Published: BMC 2008-10-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/27/1/50

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http://www.jeccr.com/content/27/1/50

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