Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo

TDP-43 is a predominantly nuclear DNA/RNA binding protein that is often mislocalized into insoluble cytoplasmic inclusions in post-mortem patient tissue in a variety of neurodegenerative disorders including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD). The underlying causes...

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Bibliographic Details
Main Authors: Charlton G. Otte, Tyler R. Fortuna, Jacob R. Mann, Amanda M. Gleixner, Nandini Ramesh, Noah J. Pyles, Udai B. Pandey, Christopher J. Donnelly
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neurobiology of Disease
Subjects:
TDP-43
ALS/FTD
LATE
RNA binding proteins
optoTDP43
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303533

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http://www.sciencedirect.com/science/article/pii/S0969996120303533

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